Dr. Satchin Panda: Intermittent Fasting to Improve Health, Cognition & Longevity | Huberman Lab

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In this episode, my guest is Satchin Panda, PhD, professor and the director of the Regulatory Biology Laboratories at the Salk Institute for Biological Studies. We discuss his lab’s discovery that “time-restricted eating” (TRE) aka intermittent fasting, is beneficial effects for metabolic health and longevity. Dr. Panda explains how TRE, and also longer fasts, can positively impact obesity, diabetes, cardiovascular health, age-related chronic diseases, and improve mood and cognitive performance. He also describes how the timing of eating, light exposure and exercise that ~50% of all people engage in, negatively impacts their health and explains how specific simple adjustments to these can positively shift their subjective feelings of health and biomarkers of cardiovascular function, glucose regulation and metabolism. We discuss how our circadian behaviors, which include our patterns of eating, sleeping and socializing, have an enormous impact on our biology, mood and health and how by simply confining our calorie consumption to a semi-regular daily window, can positively impact our physical health, mental health and longevity.

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Other Resources
My Circadian Clock app:
Ontime Health app:

Revival of light signalling in the postmortem mouse and human retina:
Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice:
Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial:
Embers of society: Firelight talk among the Ju/’hoansi Bushmen:
Circadian Entrainment to the Natural Light-Dark Cycle across Seasons and the Weekend:
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial:
Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer Community:
Daily Eating Patterns and Their Impact on Health and Disease:

The Circadian Code:
The Circadian Diabetes Code:

00:00:00 Dr. Satchin Panda
00:03:02 Sponsors: HVMN, Eight Sleep, Thesis, Momentous
00:07:24 Time-Restricted Eating (TRE), Calorie Restriction (CR) & Health
00:14:38 Mealtimes & Circadian Clock
00:21:34 Circadian Rhythm, Meal Anticipation, Digestion
00:25:28 Breaking a Fast, Burning Fat
00:32:49 Sponsor: AG1 (Athletic Greens)
00:34:04 CR, Time Restricted Eating, Circadian Rhythm & Longevity
00:47:20 Gender, Hormones & CR; Relative Energy Deficient in Sports (REDS)
00:52:40 Physical Activity, Nutrition & Feeding Window
00:59:04 Nutrition Timing, Quality & Quantity; Low- Carbohydrate Diet
01:03:00 Caffeine, Nighttime Socialization, Fire, Breakfast
01:15:07 Sponsor: InsideTracker
01:16:20 Circadian Rhythm, “Night Owls” & Genetics
01:26:37 Morning vs. Nighttime Discussions, “Me Time”
01:30:08 Light Sensitivity & “Night Owls”; Puberty, Melatonin
01:36:05 Shift Workers, Health & Disease
01:45:43 Artificial Lights, Young Adults & Sleep, Metabolic Dysfunction
01:50:59 Firefighters, Sleep & TRE; Cardiovascular Health, Blood Glucose
02:05:18 Shift Workers & Sleep; Alcohol & Caffeine
02:09:15 12- Hour Feeding Window for Adults & Children, Sleep
02:22:10 Meal Timing
02:25:20 “Complete Fast”, Longer Fasts, Physical Health & Mental Health
02:28:12 “Fat Fasting”, Blood Glucose & Insulin
02:31:57 Fasting, Metformin, Rapamycin & Longevity; Human Applicability?
02:39:14 Circadian Rhythm & Metabolism
02:41:36 Ontime Health App, Circadian Clock App
02:46:17 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter


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